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骨骼疾病及损伤

关节炎

关节炎是由关节中的炎症引起的。它会导致受影响关节的疼痛和僵硬,通常随着年龄增长而加重。关节炎有两种常见类型:骨关节炎和类风湿性关节炎。

骨关节炎是最常见的关节炎类型,它发生在关节软骨——位于骨头之间的连接组织——退化时。而类风湿性关节炎则是一种自身免疫性疾病,当免疫系统攻击并破坏健康组织时,免疫系统会攻击并破坏关节内的光滑衬里(称为滑膜),导致疼痛和炎症。

由于干细胞具有再生能力,干细胞正在被探索用于治疗关节炎。人们的希望是干细胞能够再生受关节炎影响的组织。

临床试验课题 临床试验编号
Looking at the safety and efficacy of allogeneic (from a donor) mesenchymal stem cell infusion to treat new onset Rheumatoid Arthritis. NCT03186417
National Institute of Arthritis and Musculoskeletal and Skin Diseases, USA
Can allogeneic umbilical tissue-derived stem cells be used to induce remission of rheumatoid arthritis in patients that don’t respond to standard anti-rheumatoid drug therapy? NCT01985464
Stem Cell Institute, Panama
Exploring the use of autologous adipose-derived mesenchymal stem cells (HD-adMSCs) as a possible treatment for rheumatoid arthritis. NCT03691909
Hope Bioscience, Texas, USA
Looking at the safety and efficacy of allogeneic (from a donor) mesenchymal stem cell infusion to treat new onset Rheumatoid Arthritis. NCT03186417
National Institute of Arthritis and Musculoskeletal and Skin Diseases, USA
Safety and effectiveness of using amniotic and umbilical cord tissue to treat the following conditions: orthopaedic, neurological, urologic, autoimmune, renal, cardiac and pulmonary. NCT03899298
R3 Stem Cell, USA
Tolerability of umbilical cord tissue derived mesenchymal stem cell product BX-U001 for treating refractory rheumatoid arthritis NCT03828344
Baylx Inc, California
How does implanting allogeneic mesenchymal stem cells derived umbilical cord Wharton’s Jelly influence the pain and functioning in patients with knee osteoarthritis? NCT03337243
Scott Medical Health Center, Pittsburgh, Pennsylvania
Is there a maximum tolerated dose umbilical cord derived mesenchymal stem cells that can be used to treat knee osteoarthritis? NCT03357770
Peking University People’s Hospital
Can allogeneic umbilical cord mesenchymal stem cells be used to manage osteoarthritis? NCT03800810
Indonesia University
Multicenter trial of stem cell therapy for osteoarthritis NCT03818737
Emory University

脊髓受伤

脊髓损伤是指脊髓受损,导致其功能发生变化,可能是暂时性的,也可能是永久性的。根据损伤发生的位置,脊髓损伤可以分为完全性损伤,所有的感觉和肌肉功能丧失,或不完全性损伤,部分神经信号能够通过受损的脊髓区域传递。脊髓损伤常见的症状包括失去感觉和肌肉功能,通常发生在损伤部位以下的身体部分。

2019年,日本成为世界上第一个批准使用干细胞治疗脊髓损伤的国家。

临床试验课题 临床试验编号
Exploring the safety and effectiveness of injecting allogeneic (from donor) umbilical cord derived mesenchymal stem cells into the spinal canal to treat patients with late stage chronic spinal cord injury. NCT03505034
West China Hospital & Shanghai East Hospital
Exploring the safety and effectiveness of injecting allogeneic (from donor) umbilical cord derived mesenchymal stem cells into the spinal canal to treat patients with sub-acute spinal cord injury. NCT03521336
West China Hospital & Shanghai East Hospital
Exploring the safety and effectiveness of injecting allogeneic (from donor) umbilical cord derived mesenchymal stem cells into the spinal canal to treat patients with early stage chronic spinal cord injury. NCT03521323
West China Hospital & Shanghai East Hospital
Can mesenchymal stem cells derived from fat tissue be safely administered into the cerebrospinal fluid (CSF) of patients with spinal cord injury? NCT03308565
Mayo Clinic, USA
Safety study of transplanting human spinal cord-derived neural stem cells to treat chronic spinal cord injury. NCT01772810
Neuralstem Inc., Maryland, USA
Potential benefits of using autologous (from donor) bone marrow derived stem cells to treat spinal cord injury with impaired motor or sensory function. NCT03225625
The Healing Institute, Florida, USA
Safety and tolerability of FAB117-HC (product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed by H2O2 in culture) administered at a single-time point to patients with spinal cord injury. NCT02917291
Histocell S.L., Spain
How does direct transplantation (through surgery) of bone marrow-derived mesenchymal stem cell (cellgram-spine) affect injured spinal cords? NCT01676441
Pharmicell Co., Ltd., South Korea
Use of autologous (from patient) bone marrow mesenchymal stem cell transplant to treat patients with chronic and complete spinal cord injury. NCT02574585
Hospital Sao Rafael, Brazil

软骨修复

软骨是连接组织,它在关节处为骨头的末端提供类似橡胶的保护。它还是耳朵、鼻子、气道、脊髓中的椎间盘和胸廓的结构组成部分。软骨由一种称为软骨细胞的特化细胞构成。

当骨头之间的软骨磨损时,会导致像骨关节炎这样的病症,并造成关节损伤。干细胞正在被研究作为一种潜在的治疗方法,用于促进软骨的再生。

临床试验课题 临床试验编号
The efficacy and safety of transplanting umbilical cord mesenchymal stem cells in patients with knee cartilage damage. NCT02776943
South China Research Center for Stem Cell and Regenerative Medicine
The efficacy and safety of using umbilical cord mesenchymal stem cells to treat articular cartilage defect of the knee. NCT02291926
The Fifth Affiliated Hospital of Guangzhou Medical University, China
Study of allogeneic-unrelated umbilical cord blood-derived mesenchymal stem cell product (Cartistem®) in patients with articular cartilage defect or injury. NCT01041001
Medipost Co Ltd., South Korea
A long term follow-up study looking at the safety and effectiveness of CARTISTEM®, in repair of cartilage injury or defects, compared with microfracture. NCT01626677
Medipost Co Ltd., South Korea

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